24 300
правок
Спорт-вики — википедия научного бодибилдинга
Изменения
Нет описания правки
Рекомендуемая доза - 200-400 мг в неделю
Прогестерон, пролактин
19-nortestosterone, also known as nandrolone, is a SARM. Nandrolone is 5-alpha reduced to form 5-dihydro metabolites that bind weakly to the androgen receptor in tissues such as the prostate, seminal vesicles and the scalp. On the other hand, nandrolone binds strongly to the AR in skeletal muscle where there is no 5-alpha reductase activity. Therefore, nandrolone is more potent in skeletal muscle so we say it is selective for skeletal muscle.
Dihydrotestosterone is also a SARM. Dihydrotestosterone (DHT) binds very strongly to the AR in the prostate but is deactivated to 3-alpha hydroxymetabolites in skeletal muscle which are inactive. This means that dihydrotestosterone is a selective activator of the prostate. In one study, nandrolone was shown to have an anabolic/androgenic ratio of 390/39 meaning that it is ten-fold selective for skeletal muscle over the prostate. DHT was shown to have an anabolic/androgenic ratio of 152/268 meaning that it is about 1.75 fold selective for the prostate over skeletal muscle.
Non-steroidal SARMS are also different in that they are pure androgen receptor activators. That is, they do not interact with many of the other targets that steroidal androgens modulate such as, the progesterone receptor, 11-beta hydroxylase, the estrogen receptor through aromatization, aromatase, or the other non-AR targets.
